Molecular insights into the Darwin paradox of coral reefs from the sea anemone Aiptasia

by Guoxin Cui, Migle K. Konciute, LorraineLing, Luke Esau, Jean-Baptiste Raina, Octavio R. Salazar, JasonS. Presnell, NilsRädecker, Huawen Zhong, JessicaMenzies, PhillipA. Cleves, Yi Jin Liew, CoryJ. Krediet, Val Sawiccy, MahaJ. Cziesielski, Paul Guagliardo, JeremyBougoure, MathieuPernice, Heribert Hirt, ChristianR. Voolstra, Virigina M. Weis, Pringle John R., Manuel Aranda
Journal Year: 2023 DOI: doi: 10.1126/sciadv.adf7108


G. Cui, M. K. Konciute, L. Ling, L. Esau, J. B. Raina, B. Han, O. R. Salazar, J. Presnell, N. Rädecker, H. Zhong, J. Menzies, P. A. Cleves, Y. J. Liew, C. J. Krediet, V. Lapacek, M. J. Cziesielski, P. Guagliardo, J. Bougoure, M. Pernice, H. Hirt, C. R. Voolstra, V. M. Weis, J. R. Pringle, M. Aranda (2023). “Molecular insights into the Darwin paradox of coral reefs from the sea anemone Aiptasia”. Science Advances, 2023 Mar 17;9(11):eadf7108. doi: 10.1126/sciadv.adf7108


Symbiotic cnidarians such as corals and anemones form highly productive and biodiverse coral reef ecosystems in nutrient-poor ocean environments, a phenomenon known as Darwin’s paradox. Resolving this paradox requires elucidating the molecular bases of efficient nutrient distribution and recycling in the cnidarian-dinoflagellate symbiosis. Using the sea anemone Aiptasia, we show that during symbiosis, the increased availability of glucose and the presence of the algae jointly induce the coordinated up-regulation and relocalization of glucose and ammonium transporters. These molecular responses are critical to support symbiont functioning and organism-wide nitrogen assimilation through glutamine synthetase/glutamate synthase–mediated amino acid biosynthesis. Our results reveal crucial aspects of the molecular mechanisms underlying nitrogen conservation and recycling in these organisms that allow them to thrive in the nitrogen-poor ocean environments.



Aiptasia Glucose Ammonium Nutrient recycling Darwin Paradox Whole-organism nitrogen assimilation Symbiosis