The Coral Symbiomics Lab
Red Sea Research Center
Division of Biological and Environmental Science and Engineering

Publications in 2006

A Segmentation Gene in Tribolium Produces a Polycistronic mRNA that Codes for Multiple Conserved Peptides

​Savard, Marques-Souza, Aranda and Tautz, “A Segmentation Gene in Tribolium Produces a Polycistronic mRNA that Codes for Multiple Conserved Peptides,” Cell 126, no. 3 (2006).
Joël Savard, Henrique Marques-Souza, Manuel Aranda, Diethard Tautz
Segmentation genes, Tribolium, Polycistronic mRNA
2006
​Segmentation genes in insects are required for generating the subdivisions of the early embryo. We describe here a new member of the gap family of segmentation genes in the flour beetle Tribolium, mille-pattes (mlpt). mlpt knockdown leads to transformation of the abdominal segments into thoracic segments, providing embryos with up to ten pairs of legs. We show that there are crossregulatory interactions between mlpt and the known gap genes in Tribolium, suggesting that mlpt is itself a gap gene. The mlpt gene reveals an unusual structure, as it encodes a polycistronic mRNA that codes for four peptides. mlpt appears to be the prototype of this previously unknown gene structure in eukaryotes, as we find homologous genes with the same polycistronic arrangement in other insect genomes as well.