The Coral Symbiomics Lab
Red Sea Research Center
Division of Biological and Environmental Science and Engineering

Publications in 2010

Identification of a gene expression core signature for Duchenne muscular dystrophy (DMD) via integrative analysis reveals novel potential compounds for treatment

​Ichim-Moreno, Aranda and Voolstra, “Identification of a gene expression core signature for Duchenne muscular dystrophy (DMD) via integrative analysis reveals novel potential compounds for treatment”. IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (2010).
N. Ichim-Moreno, M. Aranda, C. R. Voolstra
biocomputing, muscle, DMD, Duchenne muscular dystrophy, gene expression core signature identification, genetic disorders, integrative analysis reveals novel potential compounds, muscle degeneration, Calcium, Cardiac disease, Degenerative diseases, Drugs,
2010

Duchenne muscular dystrophy (DMD) is a recessive X-linked form of muscular dystrophy and one of the most prevalent genetic disorders of childhood. DMD is characterized by rapid progression of muscle degeneration, and ultimately death. Currently, glucocorticoids are the only available treatment for DMD, but they have been shown to result in serious side effects. The purpose of this research was to define a core signature of gene expression related to DMD via integrative analysis of mouse and human datasets. This core signature was subsequently used to screen for novel potential compounds that antagonistically affect the expression of signature genes. With this approach we were able to identify compounds that are 1) already used to treat DMD, 2) currently under investigation for treatment, and 3) so far unknown but promising candidates. Our study highlights the potential of meta-analyses through the combination of datasets to unravel previously unrecognized associations and reveal new relationships.